This final section of Chapter 2 has five verses:

2 Timothy 2:22-26
22 Flee also youthful lusts: but follow righteousness, faith, charity, peace, with them that call on the Lord out of a pure heart. 
23 But foolish and unlearned questions avoid, knowing that they do gender strifes. 
24 And the servant of the Lord must not strive; but be gentle unto all men, apt to teach, patient, 
25 In meekness instructing those that oppose themselves; if God peradventure will give them repentance to the acknowledging of the truth; 
26 And that they may recover themselves out of the snare of the devil, who are taken captive by him at his will.

We will begin with the Barclay's commentary:

ADVICE TO A CHRISTIAN LEADER
2 Timothy 2:22–26 …paraphrased
Flee from youthful passions; run in pursuit of righteousness in the company of those who call on the Lord from a clean conscience. Have nothing to do with foolish and stupid arguments, for you know that they only breed quarrels. The servant of the Lord must not fight, rather he must be kindly to all, apt to teach, forbearing, disciplining his opponents by gentleness. It may be that God will enable them to repent, so that they will come to know the truth, and so that they will escape from the snare of the devil, when they are captured alive by God’s servant that they may do God’s will.

HERE is a passage of most practical advice for Christian leaders and teachers.

Timothy is told to flee from youthful lusts. Many commentators have made suggestions as to what these youthful lusts are. They are far more than the passions of the flesh. They include that impatience, which has never learned to make haste slowly and has still to discover that too much haste can do far more harm than good; that self-assertion, which is intolerant in its opinions and arrogant in its expression of them, and which has not yet learned to see the good in points of view other than its own; that love of debate, which tends to argue long and act little, and which will talk the night away and be left with nothing but a litter of unsolved problems; and that love of novelty, which tends to condemn a thing simply because it is old and to desire a thing simply because it is new, underrating the value of experience. One thing is to be noted – the faults of youth are the faults of idealism. It is simply the freshness and intensity of the vision which makes youth run into these mistakes. Such faults are matters not for austere condemnation but for sympathetic correction, for everyone has a virtue hidden beneath it.

Christian teachers and leaders are to aim at righteousness, which means giving both to other people and to God their due; at faith, which means loyalty and reliability which both come from trust in God; at love, which is the utter determination never to seek anything but the highest good of our neighbors, no matter what they do to us, and which has put away forever all bitterness and all desire for vengeance; and at peace, which is the right relationship of loving fellowship with God and with one another. And all these things are to be sought in the company of those who call upon the Lord. Christians must never seek to live apart and aloof from others. They must find their strength and their joy in the Christian fellowship. As John Wesley said: ‘A man must have friends or make friends; for no one ever [goes to the Kingdom] alone.’

Christian leaders must not get involved in senseless controversies which are the curse of the Church. In the modern Church, Christian arguments are usually particularly senseless, for they are seldom about great matters of life and doctrine and faith, but almost always about unimportant and trivial things. Once leaders become involved in senseless and un-Christian controversy, they have forfeited all right to lead.

Christian leaders must be kindly to all; even when they have to criticize and point out a fault, it must be done with the gentleness which never seeks to hurt. They must be apt teachers; they must not only know the truth but also be able to communicate it, and they will do that not so much by talking about it as by living in such a way that they show Christ to others. They must be forbearing; like their Master, if they are criticized they must not respond with similar criticism; they must be able to accept insult and injury, slights and humiliations, as Jesus accepted them. There may be greater sins than touchiness, but there is none which does greater damage in the Christian Church. They must discipline their opponents in gentleness; their hands must be like the hands of a surgeon, unerring to find the diseased spot, yet never for a moment causing unnecessary pain. They must love people, not browbeat them into submission to the truth.

The last sentence of this passage [verse 26] is in very complex Greek, but it seems to be a hope that God will awaken repentance and the desire for the truth in people’s hearts, so that those who are trapped by the devil may be rescued while their souls are still alive and brought into obedience to the will of God by the work of his servants. It is God who awakes the repentance; it is the Christian leaders who open the door of the Church to all who have [repentant] hearts. ~Barclay's commentary

Now to the rest of the commentaries. We will begin with the general and go to the specific.

First from the Matthew Henry Main which covers verses 23 and 24.

He cautions him against contention, and, to prevent this (2 Timothy 2:23), cautions him against foolish and unlearned questions, that tend to no benefit, strifes of words. Those who advanced them, and doted upon them, thought themselves wise and learned; but Paul calls them foolish and unlearned. The mischief of these is that they gender strifes, that they breed debates and quarrels among Christians and ministers. It is very remarkable how often, and with what seriousness, the apostle cautions Timothy against disputes in religion, which surely was not without some such design as this, to show that religion consists more in believing and practicing what God requires than in subtle disputes. - The servant of the Lord must not strive, 2 Timothy 2:24. Nothing worse becomes the servant of the Lord Jesus, who himself did not strive nor cry (Matthew 12:19), but was a pattern of meekness, and mildness, and gentleness to all, than strife and contention. The servant of the Lord must be gentle to all men, and thereby show that he is himself subject to the commanding power of that holy religion which he is employed in preaching and propagating. - Apt to teach. Those are unapt to teach who are apt to strive, and are fierce and froward. Ministers must be patient, bearing with evil. ~Matthew Henry Main

Quoted verse:
Matthew 12:19 [I will read from verse 15] ...the Pharisees conspired to destroyed Jesus for breaking the Sabbath

Matthew 12:15-19
15 But when Jesus knew it, he withdrew himself from thence: and great multitudes followed him, and he healed them all; 
16 And charged them that they should not make him known: 
17 That it might be fulfilled which was spoken by Esaias the prophet, saying, 
18 Behold my servant, whom I have chosen; my beloved, in whom my soul is well pleased: I will put my spirit upon him, and he shall shew judgment to the Gentiles. 
19 He shall not strive, nor cry; neither shall any man hear his voice in the streets. 

Now to the Matthew Henry Concise,

The more we follow that which is good, the faster and the further we shall flee from that which is evil. The keeping up the communion of saints, will take us from fellowship with unfruitful works of darkness. See how often the apostle cautions against disputes in religion; which surely shows that religion consists more in believing and practicing what God requires, than in subtle disputes. Those are unapt to teach, who are apt to strive, and are fierce and froward. Teaching, not persecution, is the Scripture method of dealing with those in error. The same God who gives the discovery of the truth, by his grace brings us to acknowledge it, otherwise our hearts would continue to rebel against it. There is no “peradventure,” [chance, doubt or uncertainty] in respect of God's pardoning those who do repent; but we cannot tell that he will give repentance to those who oppose his will. Sinners are taken in a snare, and in the worst snare, because it is the devil's; they are slaves to him. And if any long for deliverance, let them remember they never can escape, except by repentance, which is the gift of God; and we must ask it of him by earnest, persevering prayer. ~Matthew Henry Concise

I find this commentary chuck full of important principles and concepts. So I am going to break it out into parts for better understanding. We have covered most of them in past sermons and Bible studies.

1] "The more we follow that which is good, the faster and the further we shall flee from that which is evil."

That is, bring in the good, and the less than good and evil must depart. The key words in this statement are "faster" and "further." The more you actively immerse yourself in God's Word, the further and faster you will go.

2] "The keeping up the communion of saints, will take us from fellowship with unfruitful works of darkness."

There is more here than just communication with other firstfruits. It is the application of your heart and mind on the greater Body of Christ and specific members in that Body. It is manifested when you pray for others. It is also manifested in deep, intimate communication with them.

3] "See how often the apostle cautions against disputes in religion; which surely shows that religion consists more in believing and practicing what God requires, than in subtle disputes."

We have talked almost endlessly about the problems with false doctrines and going off into vain jangling [1 Timothy 1:6]. We have to...must be hearers and doers of the Word of God. The more you are doing the Word of God, the less disputes you will ever enter. The gentleness and patience will reign in your heart and mind.

4] "Teaching, not persecution, is the Scripture method of dealing with those in error."

This is what firstfruit ministers do. They do not enter into arguments. They preach a sermon. They give the other person who is seeking dispute or argument, something to read or to consider. The minister leads this individuals to truth but does not hit him over the head with it.

5] "The same God who gives the discovery of the truth, by his grace brings us to acknowledge it, otherwise our hearts would continue to rebel against it."

Ours is a God the Father and Christ-centered religion and way of life. Gods leads us to truth. He then makes us acknowledge it. Without this process, we would rebel. The more you are immersed into the Word of God, the more you will acknowledge truth. Your immersion process is one of the primary ways God leads us to truth. Another would be His intercession into our every experience of life. See the need for assiduity prayers?

6] "There is no 'peradventure,' [chance, doubt or uncertainty] in respect of God's pardoning those who do repent; but we cannot tell that he will give repentance to those who oppose his will."

Repentance is much more than just repenting of something. It is understanding that God must grant the repentance. It is understanding that we must know if we are opposing His will. It is understanding that we must know His will.

7] "Let them remember they never can escape, except by repentance, which is the gift of God; and we must ask it of him by earnest, persevering prayer."

Know that God created the concept of repentance. Know that repentance is a gift of God. Know that you cannot just invoke it or do it; you must pray always that God grant you repentance; that He gives you this gift.

Now to the specific commentaries.

I am going to go with the Barnes on this verse and break it into five parts.

1] And the servant of the Lord.
2] Must not strive. [some commentaries combine these two parts]
3] But be gentle unto all men.
4] Apt to teach.
5] Patient.

1] And the servant of the Lord.

The servant of the Lord must not strive. - Hence, should not engage in these profitless discussions. ~People's New Testament

A servant of the Lord must not strive - Eagerly or passionately. Strive - As do the vain wranglers spoken of, 2 Timothy 2:23. ~John Wesley Explanatory Notes

Quoted verse:
2 Timothy 2:23 [See Lesson] 
But foolish and unlearned questions avoid, knowing that they do gender strifes. 

And the servant of the Lord - Referring here primarily to the Christian minister, but applicable to all Christians; for all profess to be the servants of the Lord. ~Barnes Notes

And the servant of the Lord must not strive - By "the servant of the Lord" is not meant any believer in common, but a minister of the word, as Timothy was; such an one ought not to strive about words to no profit, about mere words, and in a litigious, quarrelsome manner, and for mastery and not truth; though he may, and ought to strive for the faith of the Gospel; this is praiseworthy in him: ~John Gill

2] Must not strive.

Must not strive - He may calmly inquire after truth; he may discuss points of morals, or theology, if he will do it with a proper spirit; he may “contend earnestly for the faith once delivered to the saints” Jude 1:3; but he may not do that which is here mentioned as strife. The Greek word - μάχεσθαι machesthai - commonly denotes, “to fight, to make war, to contend.” In John 6:52; Acts 7:26; 2 Timothy 2:24;, it is rendered “strove,” and “strive;” in James 4:2, “fight.” It is not elsewhere used in the New Testament. The meaning is, that the servant of Christ should be a man of peace. He should not indulge in the feelings which commonly give rise to contention, and which commonly characterize it. He should not struggle for mere victory, even when endeavoring to maintain truth; but should do this, in all cases, with a kind spirit, and a mild temper; with entire candor; with nothing designed to provoke and irritate an adversary; and so that, whatever may be the result of the discussion, “the bond of peace” may, if possible, be preserved; compare the notes at Romans 12:18. ~Barnes Notes

Quoted verses:
Jude 1:3 ...faith once delivered
Beloved, when I gave all diligence to write unto you of the common salvation, it was needful for me to write unto you, and exhort you that ye should earnestly contend for the faith which was once delivered unto the saints. 

John 6:52
The Jews therefore strove among themselves, saying, How can this man give us his flesh to eat? 

Acts 7:26
And the next day he shewed himself unto them as they strove, and would have set them at one again, saying, Sirs, ye are brethren; why do ye wrong one to another?

James 4:2
Ye lust, and have not: ye kill, and desire to have, and cannot obtain: ye fight and war, yet ye have not, because ye ask not. 

Romans 12:18
If it be possible, as much as lieth in you, live peaceably with all men. 

Commentary:

Now from the Adam Clarke:

The servant of the Lord must not strive - See on 1 Timothy 3:2 (note), 1 Timothy 3:3 (note). ~Adam Clarke

Quoted verses:
1 Timothy 3:2 [See Lesson] 
A bishop then must be blameless, the husband of one wife, vigilant, sober, of good behaviour, given to hospitality, apt to teach; 

1 Timothy 3:3 [See Lesson] 
Not given to wine, no striker, not greedy of filthy lucre; but patient, not a brawler, not covetous; 

3] But be gentle unto all men.

But be gentle unto all men - see the notes at 1 Thessalonians 2:7. The word rendered “gentle,” does not occur elsewhere in the New Testament. It means that the Christian minister is to be meek and mild toward all, not disputatious and quarrelsome. ~Barnes Notes

Quoted verse: 
1 Thessalonians 2:7
But we were gentle among you, even as a nurse cherisheth her children: 

Commentary:

But be gentle unto all men - not only to troubled minds, and wounded consciences, by supplying them with the precious promises and truths of the Gospel; and to backsliders, by restoring them in a spirit of meekness; but even to those who contradict the truth, and themselves, by mild and kind instructions. ~John Gill

4] Apt to teach.

Apt to teach - see the notes at 1 Timothy 3:2. ~Barnes Notes

Quoted verse:
1 Timothy 3:2 ...mentioned above [See Lesson] 
A bishop then must be blameless, the husband of one wife, vigilant, sober, of good behaviour, given to hospitality, apt to teach; 

Apt to teach - showing a willingness to instruct the ignorant and obstinate, and making use of abilities given for that purpose, notwithstanding all discouragements; for it follows. ~John Gill

Apt to teach - Chiefly by patience and unwearied assiduity. ~John Wesley Explanatory Notes

5] Patient.

Patient - Margin, “forbearing.” The Greek word here used does not elsewhere occur in the New Testament. It means, patient under evils and injuries. Robinson, Lexicon. Compare the Ephesians 4:2 note; Colossians 3:13 note. ~Barnes Notes

Quoted verses:
Ephesians 4:2 ...reading verses 1-3

Ephesians 4:1-3
1. I therefore, the prisoner of the Lord, beseech you that ye walk worthy of the vocation wherewith ye are called, 
2 With all lowliness and meekness, with longsuffering, forbearing one another in love; 
3 Endeavouring to keep the unity of the Spirit in the bond of peace. 

Colossians 3:13
Forbearing one another, and forgiving one another, if any man have a quarrel against any: even as Christ forgave you, so also do ye. 

Patient, or "bearing evil"; not only the infirmities of weak brethren in the church, and the reproaches and persecutions of profane men in the world; but also the contradictions and oppositions of the adversaries of truth, so as not to be irritated and provoked, or to be discouraged, and desist from the defence of the Gospel. ~John Gill

Let us finish with a few quotes on gentleness:

A Christian reveals true humility by showing the gentleness of Christ, by being always ready to help others, by speaking kind words and performing unselfish acts, which elevate and ennoble the most sacred message that has come to our world.

Nothing is so strong as gentleness, nothing so gentle as real strength.

I learned that it is the weak who are cruel, and that gentleness is to be expected only from the strong.

“If a violent person wishes to attack us, let us send him a gentle phrase as this will defuse his violence.” [Proverbs 15:1]